47 xxy, Klinefelter syndrome, xxy

XXYKindaGuy Sam Pierce

Klinefelter syndrome diagnosis a relief after childhood woes.

The Courier News Letter

47 xxy, Klinefelter syndrome, xxy

Samuel Pierce knew something was amiss growing up.

He lacked hair growth and muscle mass, experienced numerous learning difficulties and at the age of 23 his “sex drive decided to die”.

It was at that point he knew he needed some answers.

Mr Pierce, who is a chef at The Oxford in Timaru, was referred to a specialist in Christchurch, who eventually diagnosed him with Klinefelter syndrome  – a chromosomal condition that affects male physical and cognitive development.

In simple terms, Mr Pierce has an extra X chromosome.

There are varying degrees of symptoms, which often include small testicles, a lack of testosterone, breast tissue and weight gain on the hips and tummy.


Infertility is also a factor for Mr Pierce (24). “I’m sterile, so that really sucked for me,” he said.  “I was shocked because I really wanted kids.” Mr Pierce was diagnosed on November 9 last year and has since turned his attention to raising awareness in a positive way.

He has launched a YouTube channel to share his story and inspire anyone – with or without the condition – to enjoy life and achieve anything they set their mind to.

“The messages I get from people are insane, [explaining] how much I’m helping them and helping them with their kids.” – Samuel Pierce

In just three months Mr Pierce has gone from having no answers to creating a profile on social media that has amassed thousands of followers from around the world.  Among them is “another XXY guy”, Ryan Bregante, of the United States, whom Mr Pierce plans to meet when he travels there in September.

Overall, the feedback he had received was very positive.  “The messages I get from people are insane, [explaining] how much I’m helping them and helping them with their kids. People saying ‘thank you, you’ve uplifted me’,” Mr Pierce said.

“Every day I talk to about 10 to 15 new people all over the world.  “Now I know what Klinefelter syndrome is and I can help others with it.”  Mr Pierce said although his diagnosis was a shock, it was the answer he had been searching for.

“It saved my life, I believe. I know that sounds cliche, but it gives me all my answers from my whole life.”

Mr Pierce now gets regular testosterone injections.  Despite the pain that came with it, the results were worth it, he said.  “I’m now seeing body hair, muscle mass, and emotionally and physically I feel better. I’m no longer down in the dumps.”

Mr Pierce, whose social media profiles include a blog called xxykindaguy, welcomes anyone wanting to contact him to do so at xxykindaguy@yahoo.com

3 thoughts on “XXYKindaGuy Sam Pierce

  1. Hi there. We suspect my 17 yr old son has this. It’s a fight to get his pediatrician to even do a regular blood test or listen to us. His testosterone came back at 322, which is low normal. I asked for a referral to Endocrinologist but doc said he wont as his level seems normal. I’m asking him to do an LSH/FSH test next since he only did his total testosterone. If his next results are abnormal, I’ll find another doctor.
    My son plays football but can not grow any sort of muscle. Hes unusually tall for our family, he has baby fat around his belly and chest but lean long arms and long thick legs. His butt is really big too. All of his weight is in the more female pattern, ie, hips/thigh/butt.
    He also breaks bones really easily. No learning or speech issues. He is very subdued and always seems tired.

    1. If you’re doctor won’t give a referral to Endocrinologist for a chromosome analysis; you could do request lab work at private MD Labs or lab Corp. To save money, I would do the Hormone Panel For Females which costs 70.00 and does the following:

      Estradiol, serum;
      Follicle-Stimulating Hormone (FSH);
      Luteinizing Hormone (LH);
      Testosterone, Serum (Total Only);
      Complete Blood Count (CBC) with Differential: (Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes)
      Comprehensive Metabolic Profile (CMP) (includes eGFR): (A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum.)

      You’re basically looking at LH and FSH. Elevated LH and High FSH; your son is primary and needs a chromosome analysis. Make sure the the blood test is done early in morning when testosterone is at the Highest.

      I would be sure your son wants to start treatment because the treatment does come with a series of commitments and side effects. The benefits should be weighed equally, testosterone improves many aspects but I kind of regret rushing to treatment because Your son does have working testosterone production. If he would start treatment, there is no recovery for primary testicular failure.

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